Product Review:
Epien HYBENX
Simplify and Boost Healing Processes
HYBENX® from Epien is easy to use for practitioners and
offers multiple benefits to patients. [written by Kelly Tanner, PhD, RDH]
Often, dental products are
indicated for a single purpose
but, when you use the product,
you find it helps you in other ways:
HYBENX did just that. In periodontal
disease, treating what we cannot see is
the most critical aspect of care. During
scaling and root planing, microorganisms
are not entirely removed, and the
pathogens are typically treated with
antimicrobial therapies. What if we
could eradicate all microorganisms in
the sulcus? Microorganisms (bacteria,
fungi, viruses, archaea, and protists)
require water to survive.
EPIEN Medical has produced a
unique product. HYBENX makes
an electrostatic charge that attracts
water and dehydrates the environment
necessary for the microorganisms to
survive. Dead microorganisms and
tissue debris are rinsed away, and the
natural healing processes of your body
are facilitated in less than 30 seconds.
Cleared by the United States Food
and Drug Administration (FDA),
HYBENX inhibits infection and
bacterial and inflammatory disease
processes with no bacterial resistance.
Features
Features
-
Application takes seconds
-
Cleared by the FDA
-
Safe on dentin and enamel
-
Safe on porcelain, titanium, and other metals
-
No postoperative instructions
-
Offers 2 viscosity choices
-
Low Cost
HYBENX Benefits
Eradicates bacteria
Inhibits infectious and inflammatory disease processes
Single treatment from infected to a healing state
Desensitizes
Hemostatic properties
Reduction of drug resistant organisms
The Evaluation
Thirteen examiners—7 hygienists
and 6 dentists—evaluated this
product. The examiners utilized the
product to treat periodontitis, gingivitis,
and peri-implantitis, as well as
for periodontal maintenance, gingival
drying around restorative margins,
and endodontic procedures. Most of
the examiners utilized the gel solution
vs the liquid, and a few also evaluated
both the liquid and the gel.
Ease of Use and Delivery
Overall, 71% of examiners agreed
that the product allowed functional
delivery, and 69% evaluated the effect
as easy to use. The most common recommendation
was a thinner tip design
to improve access to deep pockets and
narrow spaces. From start to finish,
the use of HYBENX took 1 to 3 minutes
for the majority (76.9%) and 4 to
7 minutes for a few (23.1%).
The products used during the
evaluation contained 1 mL of solution,
and some evaluators used the entire
1-mL dose; however, most evaluators
(76.9%) stated that they would prefer
a 0.2-mL or 0.5-mL dose, depending
on the procedure.Thirteen examiners—7 hygienists
and 6 dentists—evaluated this
product. The examiners utilized the
product to treat periodontitis, gingivitis,
and peri-implantitis, as well as
for periodontal maintenance, gingival
drying around restorative margins,
and endodontic procedures. Most of
the examiners utilized the gel solution
vs the liquid, and a few also evaluated
both the liquid and the gel.
Periodontal Resolution
Evaluators reported average (61.54%)
to excellent (23.08%) outcomes of the
periodontal resolution. Some commented
that they were unable to evaluate
the effects of the product because
they placed the solution during initial
therapy, and they were not able to
assess improvement. Evaluators rating
the product as excellent remarked on
the noticeable change in pocket depth
and stated they would like to continue
evaluating for long-term resolution for
scientific benchmarking. Of the 6 dentists,
only 5 used the product to treat
peri-implantitis; 3 reported average results and 2 reported excellent results.
Most (76.9%) evaluators noticed
patient improvement after a single
treatment using HYBENX, and
the remainder reported not having
enough time to evaluate progress.
Need for Retreatment
When evaluating the need to re-treat
pockets after placement during periodontitis
or peri-implantitis, 4 of the
6 participating dentists reported no
need to re-treat. At the same time, the
remaining clinicians stated it was too
soon for reevaluation because of initial
placement. Comments were provided
that fewer sites required retreatment
upon evaluation, but only a few. If
retreatment was needed, the majority
re-treated at 3 to 4 weeks with an average
(60%) to excellent (40%) outcome
for patients given new appointments
for reevaluation. The remainder of the
evaluations needed to occur due to
adequate time lapse for reevaluation.
One participant commented that it
was difficult to determine whether
the improvement was related to
HYBENX.
Most examiners reported utilizing
adjunctive therapies such as laser
therapy, minocycline HCl (Arestin),
chlorhexidine, Perio Protect, and ozone,
whereas 3 reported not using periodontal
decontaminants. Most respondents
(8) did not utilize HYBENX before
and after treatment for scaling and root
planning. Comments indicated the
product was not applied post treatment
because the directions for use did not
indicate reapplication after treatment.
HYBENX was reported to be 100%
beneficial for hemostasis and the sealing
of nerve endings for those who utilized
the product.
Patient Experience
Patients’ experience with HYBENX
was rated as good (69%) and average
(30.7%), and comments stated that
clinicians should have asked about
the patient experience and that it may
be better to understand the patient
experience with a split-mouth/samepatient
study. An additional comment
was provided that the patient reported
a burning sensation with the product
during treatment and did not like the
product’s taste.
The Surprise Benefit
It was a pleasure to evaluate HYBENX
in our educational institution. The
most surprising benefit of this product
was that it softened tenacious calculus
into a clay-like texture. Instead of 20
minutes to remove tenacious calculus,
it took us half the time, and it increased
the patient’s comfort and our field of
vision because of the hemostatic properties.
I now have students evaluating
the need for HYBENX during patient
care to assist with patient management
and efficiency. The softening of
calculus is a unique advantage that
can impact efficiency, improve patient
comfort during and after procedures,
and reduce musculoskeletal fatigue.
Overall Evaluation Summary
Evaluator
Favorite Features
- Instant results
- Viscosity of gel
- Delivery system and easy to use
- Not just for single sites but for the whole mouth
- Beneficial to healing
- Significantly softened the calculus
- Reduced bleeding during scaling and root planing
- No antibiotic component
Directions & Indications Recommendations
- High-volume evacuation needs to be utilized when rinsing product
- Can be used before and
after procedure - Call out product’s additional
benefits, such as dentinal
desensitization, hemostasis,
and reduced gingival
sensitivity during treatment - How much of the product
should be used during the
procedure? How much is
too much or too little? - Provide decision tree for
easier treatment planning - Provide guidance on whether
this is a reimbursable
procedure and range for cost - Provide guidance for how
long results should last
for desensitization as a
decontaminate and analgesic - Provide guidance on frequency
of periodontal reevaluation
and whether this should
be utilized at periodontal
maintenance appointments
Product/Delivery Design Recommendations
- Need for a thinner tip
- Remove red dye component
for potential allergies
In summary, HYBENX is an
outstanding product with excellent
promise and multiple benefits. Minor
adjustments such as additional directions,
decision-making tools, and a
thinner tip will benefit the clinician
and increase overall satisfaction and
usage. These will help providers
understand how it can improve clinical
outcomes and the patient experience,
adding overarching value to the
appointment. Most (69.2%) evaluators
would recommend HYBENX,
and 23% would likely recommend
it based on treatment use. At the
same time, 1 could not recommend it
because of the need for additional evaluation
and cases to provide a recommendation.
Most evaluators (69.2%)
stated that they would continue using
HYBENX for periodontal treatment
workflow depending on how many
sites were involved, whereas 30.7%
reported they would continue utilizing
the product. For this reason, we are
happy to issue the Catapult Vote of
Confidence for this product.
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